The novelty of this Project lies in using a multidisciplinary approach (microbiology, physiology, biochemistry and molecular biology) to address the problem of black rot control from two distinct angles, involving in-depth characterization of: (i) the selected biocontrol candidate(s) and mechanisms underlying their antagonistic activity against X. campestris pv. campestris to develop the most efficient biocontrol strategy and (ii) cabbage plants treated with biocontrol candidate(s) to identify key metabolites playing a role in the plant’s defense mechanisms against the pathogen. DNA metabarcoding approach will provide insight into the so far unexplored complex bacterial communities inhabiting the cabbage cv. Futoški, while simultaneously enabling the evaluation of changes in microbiome’ homeostasis upon “introduction” of biocontrol candidate(s).